O29 Aberrant expression of BMP8A and the BMPRs involves in the progression of breast cancer

Abstract Introduction Role of Bone morphogenetic protein 8A (BMP8A) and BMP receptors (BMPRs) in the tumourigenesis progression breast cancer remains elusive. Present study aims to investigate expression BMP8A related BMPRs their clinical implication. Method Expression was analysed using RNA sequencing data TCGA cohort. Findings were further validated a meta gene array dataset (E-MDTA6703, n = 2302). STRING applied explore predicted BMP8A. Clinical relevance deregulated assessed both ANOVA Kaplan-Meier tests. Correlation with markers proliferation invasion evaluated Spearman test. Result Analysis datasets revealed that BMPR1B highly expressed while ACVRL1, ACVR1, BMPR1A, ACVR1C, TGFBR2, TGFBR3, BMPR2 ACVR2A lower-expressed compared normal controls. Expressions BMPR1B, BMPR2, ACVR2B correlated cancers. Overall survival group higher shorter(median= 122.3 months), P 0.012 group(median 215.2 months). No significant difference observed tumours according staging lymph node involvement. Positive correlations found between tumour proliferation, EMT, angiogenic markers. Conclusion is increased correlates poor prognosis. The might be involved signal transduction co-regulate responsive genes cellular functions which yet investigated. Take-home Message